Cyclin E2

Search for
Structures	Swiss-model
Domains	InterPro

Cyclin E2
Cyclin E2
Identifiers
Symbol	CCNE2
NCBI gene	9134
HGNC	1590
OMIM	603775
RefSeq	NM_057749
UniProt	O96020
Other data
Locus	Chr. 8 q22.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

CCNE2
Identifiers
Aliases	CCNE2, CYCE2, cyclin E2
External IDs	OMIM: 603775; MGI: 1329034; HomoloGene: 7660; GeneCards: CCNE2; OMA:CCNE2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,896,678 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,204,779 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; C1 segment; ; inferior ganglion of vagus nerve; ; bone marrow; ; ganglionic eminence; ; testicle; ; ventricular zone; ; gonad; ; bone marrow cell; ; subthalamic nucleus;
	Top expressed in
	spermatocyte; ; primitive streak; ; human fetus; ; tail of embryo; ; genital tubercle; ; abdominal wall; ; yolk sac; ; medial ganglionic eminence; ; fetal liver hematopoietic progenitor cell; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase binding; protein kinase activity;
Cellular component	cytosol; nucleus; nucleoplasm; cyclin E2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; centrosome;
Biological process	cell division; cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; DNA replication initiation; regulation of cell cycle; telomere maintenance; homologous chromosome pairing at meiosis; chromosome organization involved in meiotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; protein phosphorylation; regulation of mitotic nuclear division; positive regulation of cell population proliferation; positive regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	9134
	12448
	ENSG00000175305
	ENSMUSG00000028212
	O96020
	Q9Z238
	NM_004702; NM_057735; NM_057749
	NM_001037134; NM_001282943; NM_009830
	NP_477097
	NP_001032211; NP_001269872; NP_033960
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).⁵ It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.⁵

References

GRCh38: Ensembl release 89: ENSG00000175305 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028212 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.

Zariwala M, Liu J, Xiong Y (1998-11-26). "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins". Oncogene. 17 (21): 2787–2798. doi:10.1038/sj.onc.1202505. ISSN 0950-9232. PMID 9840943. S2CID 7340570.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028212 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9858585-5] Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.

1

2

3

4

5