CUGBP2

CELF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MY7, 2MY8, 4LJM, 4LMZ, 4TLQ
Identifiers
Aliases	CELF2, BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR, CELF-2, CUG-BP2, CUGBP, Elav-like family member 2, CUGBP Elav-like family member 2, DEE97
External IDs	OMIM: 602538; MGI: 1338822; HomoloGene: 4783; GeneCards: CELF2; OMA:CELF2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	11,336,675 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	7,509,563 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; orbitofrontal cortex; ; entorhinal cortex; ; trabecular bone; ; middle temporal gyrus; ; postcentral gyrus; ; Brodmann area 46; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; germinal epithelium;
	Top expressed in
	Rostral migratory stream; ; lateral septal nucleus; ; olfactory tubercle; ; nucleus accumbens; ; anterior amygdaloid area; ; subiculum; ; barrel cortex; ; ganglionic eminence; ; olfactory bulb; ; medial dorsal nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; RNA binding; pre-mRNA binding; mRNA binding;
Cellular component	cytoplasm; nucleus; ribonucleoprotein complex;
Biological process	mRNA processing; RNA processing; regulation of heart contraction; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	10659
	14007
	ENSG00000048740
	ENSMUSG00000002107
	O95319
	Q9Z0H4
NM_001025076; NM_001025077; NM_001083591; NM_006561; NM_001326317;
	NM_001326318; NM_001326319; NM_001326320; NM_001326321; NM_001326323; NM_001326324; NM_001326325; NM_001326326; NM_001326327; NM_001326328; NM_001326329; NM_001326330; NM_001326331; NM_001326332; NM_001326333; NM_001326334; NM_001326335; NM_001326336; NM_001326337; NM_001326338; NM_001326339; NM_001326340; NM_001326341; NM_001326342; NM_001326343; NM_001326344; NM_001326345; NM_001326346; NM_001326347; NM_001326348; NM_001326349; NM_001394502; NM_001394513; NM_001394517; NM_001394518; NM_001394519
NM_001110228; NM_001110229; NM_001110230; NM_001110231; NM_001110232;
	NM_001160292; NM_001160293; NM_010160; NM_183219; NM_001310447; NM_001347094
NP_001020247; NP_001020248; NP_001077060; NP_001313246; NP_001313247;
	NP_001313248; NP_001313249; NP_001313250; NP_001313252; NP_001313253; NP_001313254; NP_001313255; NP_001313256; NP_001313257; NP_001313258; NP_001313259; NP_001313260; NP_001313261; NP_001313262; NP_001313263; NP_001313264; NP_001313265; NP_001313266; NP_001313267; NP_001313268; NP_001313269; NP_001313270; NP_001313271; NP_001313272; NP_001313273; NP_001313274; NP_001313275; NP_001313276; NP_001313277; NP_001313278; NP_006552
NP_001103698; NP_001103699; NP_001103700; NP_001103701; NP_001103702;
	NP_001153764; NP_001153765; NP_001297376; NP_001334023; NP_034290; NP_001393762; NP_001393763; NP_001393764; NP_001393770; NP_001393771; NP_001393772; NP_001393773; NP_001393774; NP_001393775; NP_001393776; NP_001393777; NP_001393778; NP_001393779; NP_001393780; NP_001393781; NP_001393783; NP_001393784; NP_001393787; NP_001393846; NP_001393847; NP_001393848; NP_001393849; NP_001393850; NP_001393851; NP_001393852; NP_001393853; NP_001393854; NP_001393855; NP_001393856; NP_001393857; NP_001393858; NP_001393859; NP_001393860; NP_001393861; NP_001393862; NP_001393863; NP_001393871; NP_001393872; NP_001393873; NP_001393874; NP_001393875; NP_001393876; NP_001393877; NP_001393878; NP_001393879; NP_001393880; NP_001393881; NP_001393882; NP_001393883; NP_001393884; NP_001393885; NP_001393886; NP_001393887; NP_001393888; NP_001393889; NP_001393890; NP_001393891; NP_001393892; NP_001393893; NP_001393894; NP_001393895; NP_001393896; NP_001393897; NP_001393898; NP_001393899; NP_001393900; NP_001393901; NP_001393902; NP_001393903; NP_001393904; NP_001393905; NP_001393906; NP_001393907; NP_001393908; NP_001393909; NP_001393910; NP_001393911
	Wikidata
View/Edit Human	View/Edit Mouse

CUGBP, Elav-like family member 2, also known as Etr-3 is a protein that in humans is encoded by the CELF2 gene.⁵⁶⁷

Members of the CELF/BRUNOL protein family are RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.⁷

Interactions

CUGBP2 has been shown to interact with A1CF.⁸

References

GRCh38: Ensembl release 89: ENSG00000048740 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002107 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.
Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.
"Entrez Gene: CELF2 CUGBP, Elav-like family member 2".
Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50). United States: 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.

External links

Human CELF2 genome location and CELF2 gene details page in the UCSC Genome Browser.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Choi DK, Ito T, Tsukahara F, et al. (1999). "Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein". Gene. 237 (1): 135–42. doi:10.1016/S0378-1119(99)00312-1. PMID 10524244.
Good PJ, Chen Q, Warner SJ, Herring DC (2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J. Biol. Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
Ladd AN, Charlet N, Cooper TA (2001). "The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401. doi:10.1006/geno.2001.6558. PMID 11414768.
Anant S, Henderson JO, Mukhopadhyay D, et al. (2002). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50): 47338–51. doi:10.1074/jbc.M104911200. PMID 11577082.
Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42. doi:10.1007/s00109-002-0331-9. PMID 12110949. S2CID 24098272.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mukhopadhyay D, Houchen CW, Kennedy S, et al. (2003). "Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2". Mol. Cell. 11 (1): 113–26. doi:10.1016/S1097-2765(03)00012-1. PMID 12535526.
Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
Mukhopadhyay D, Jung J, Murmu N, et al. (2004). "CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury". Ann. N. Y. Acad. Sci. 1010 (1): 504–9. Bibcode:2003NYASA1010..504M. doi:10.1196/annals.1299.093. PMID 15033780. S2CID 38581539.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Murmu N, Jung J, Mukhopadhyay D, et al. (2004). "Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13873–8. Bibcode:2004PNAS..10113873M. doi:10.1073/pnas.0406066101. PMC 518846. PMID 15358864.
Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Chen Z, Eggerman TL, Patterson AP (2007). "ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G53–65. doi:10.1152/ajpgi.00118.2006. PMID 16920700.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048740 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002107 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7869393-5] Hwang DM, Hwang WS, Liew CC (Mar 1995). "Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system". J Mol Cell Cardiol. 26 (10): 1329–33. doi:10.1006/jmcc.1994.1151. PMID 7869393.

[pmid9887331-6] Lu X, Timchenko NA, Timchenko LT (Mar 1999). "Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy". Hum Mol Genet. 8 (1): 53–60. doi:10.1093/hmg/8.1.53. PMID 9887331.

[entrez-7] "Entrez Gene: CELF2 CUGBP, Elav-like family member 2".

[pmid11577082-8] Anant, S; Henderson J O; Mukhopadhyay D; Navaratnam N; Kennedy S; Min J; Davidson N O (Dec 2001). "Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor". J. Biol. Chem. 276 (50). United States: 47338–51. doi:10.1074/jbc.M104911200. ISSN 0021-9258. PMID 11577082.

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