Article · Wikipedia archive · Last revised Jul 18, 2026

CTW0404

CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT2A receptor, with neutral or negative modulation of the related 5-HT2B and 5-HT2C subtypes. It does not produce the head-twitch response in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.

Last revised
Jul 18, 2026
Read time
≈ 1 min
Length
243 w
Citations
4
Source
Wikipedia ↗
CTW0404
Identifiers
  • (2S,4R)-N-(2-morpholin-4-ylethyl)-4-(2-phenylethyl)piperidine-2-carboxamide
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC20H31N3O2
Molar mass345.487 g·mol−1
3D model (JSmol)
  • C1CN[C@@H](C[C@@H]1CCC2=CC=CC=C2)C(=O)NCCN3CCOCC3
  • InChI=1S/C20H31N3O2/c24-20(22-10-11-23-12-14-25-15-13-23)19-16-18(8-9-21-19)7-6-17-4-2-1-3-5-17/h1-5,18-19,21H,6-16H2,(H,22,24)/t18-,19+/m1/s1
  • Key:YQSGRDPBXKGAPX-MOPGFXCFSA-N

CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT2A receptor, with neutral or negative modulation of the related 5-HT2B and 5-HT2C subtypes. It does not produce the head-twitch response in animal studies, and reduces the head-twitch response produced by DOI, suggesting that it may be a biased allosteric modulator selective for certain signalling pathways.1234

See also

See also

References

References

  1. Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, et al. (July 2020). "Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties". Journal of Medicinal Chemistry. 63 (14): 7529–7544. doi:10.1021/acs.jmedchem.9b01953. PMC 8434884. PMID 32567857.
  2. Salinsky LM, Merritt CR, Zamora JC, Giacomini JL, Anastasio NC, Cunningham KA (2023). "μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges". Frontiers in Pharmacology. 14 1239159. doi:10.3389/fphar.2023.1239159. PMC 10598667. PMID 37886127.
  3. Zamora JC, Merritt CR, Bolinger AA, Fox RG, Wild CT, Wold EA, et al. (2024). "Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds". The Journal of Pharmacology and Experimental Therapeutics. 389: 87. doi:10.1124/jpet.087.985400.
  4. WO 2023/023287, Zhou J, Cunningham KA, Bolinger AA, Anastasio NC, "Novel heterocyclic compounds as serotonin (5-ht) 5-ht2a and 5-ht2c receptor positive allosteric modulators.", published 22 February 2024, assigned to The Board of Regents of the University of Texas System