Article · Wikipedia archive · Last revised Jul 29, 2026

CT-868

CT-868 is an experimental "biased dual GLP-1 and GIP receptor modulator that exhibits no arrestin coupling or receptor internalization at either receptor". It is developed by Carmot Therapeutics for diabetes and obesity. The drug is taken by subcutaneous injection.

Last revised
Jul 29, 2026
Read time
≈ 1 min
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221 w
Citations
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Wikipedia ↗
CT-868
Clinical data
Other namesCT868; RG-6641; RG6641
Routes of
administration		Subcutaneous injection1
Drug classGLP-1 receptor agonist; GIP receptor agonist; Antidiabetic agent; Anti-obesity agent

CT-868 is an experimental "biased dual GLP-1 and GIP receptor modulator that exhibits no arrestin coupling or receptor internalization at either receptor". It is developed by Carmot Therapeutics for diabetes and obesity. The drug is taken by subcutaneous injection.1234

References

References

  1. "CT 868". AdisInsight. 7 August 2025. Retrieved 4 April 2026.
  2. Chakravarthy MV, Elliott MA, Acosta L, Sonnenberg GE, Bialonczyk D, Wu J, Argüelles-Tello FA, Garcia-Reza R, González-González JG, Hansen SK, Frias JP (March 2026). "Efficacy and safety of CT-868, a novel, fully biased, dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist, in type 2 diabetes: A double-blind, randomized placebo controlled phase 2 trial". Diabetes Obes Metab. 28 (3): 1673–1682. doi:10.1111/dom.70006. PMC 12890765. PMID 40762050.
  3. Chakravarthy, Manu; Hernandez, Moises; Elliott, Michael; Macias, Alejandra; Hansen, Stig K.; Hompesch, Marcus (20 June 2023). "774-P: Weight-Independent Effects of CT-868, a Signaling Biased Dual GLP-1/GIP Receptor Modulator, on Glucose Homeostasis in Overweight and Obese Adults with Type 2 Diabetes". Diabetes. 72 (Supplement_1). doi:10.2337/db23-774-P. S2CID 259219222.
  4. Rodriguez, Ruben; Tracy, Ted; Morales, Marikris; Hergarden, Anne; Lam, Davina; Krishnan, Shyam; Hansen, Stig K.; Chakravarthy, Manu (20 June 2023). "1649-P: Biased GLP-1 Improves Weight Loss with Additional Benefits on Glucose Homeostasis via Biased GIP in Diabetic Rodent Models". Diabetes. 72 (Supplement_1). doi:10.2337/db23-1649-P. S2CID 259427049.