CSRP1

CSRP1
Identifiers
Aliases	CSRP1, CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286, cysteine and glycine rich protein 1
External IDs	OMIM: 123876; MGI: 88549; HomoloGene: 37874; GeneCards: CSRP1; OMA:CSRP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	201,509,456 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,679,970 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; muscle layer of sigmoid colon; ; saphenous vein; ; body of uterus; ; left uterine tube; ; gastric mucosa; ; tail of epididymis; ; smooth muscle tissue;
	Top expressed in
	ascending aorta; ; aortic valve; ; tunica media of zone of aorta; ; seminal vesicula; ; uterus; ; deep cerebellar nuclei; ; globus pallidus; ; umbilical cord; ; pyloric antrum; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; RNA binding; zinc ion binding;
Cellular component	extracellular exosome; focal adhesion; nucleus;
Biological process	platelet aggregation;
	Sources:Amigo / QuickGO
Orthologs
	1465
	13007
	ENSG00000159176
	ENSMUSG00000026421
	P21291
	P97315
	NM_004078; NM_001144773; NM_001193570; NM_001193571; NM_001193572
	NM_007791; NM_001360782
	NP_001180499; NP_001180500; NP_001180501; NP_004069
	NP_031817; NP_001347711
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine and glycine-rich protein 1 is a protein that in humans is encoded by the CSRP1 gene.⁵⁶⁷

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3.⁷

References

GRCh38: Ensembl release 89: ENSG00000159176 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026421 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.
Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910. S2CID 28018584.
"Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

External links

Human CRP genome location and CRP gene details page in the UCSC Genome Browser.
Human CSRP1 genome location and CSRP1 gene details page in the UCSC Genome Browser.

Further reading

Weiskirchen R, Günther K (2003). "The CRP/MLP/TLP family of LIM domain proteins: acting by connecting". BioEssays. 25 (2): 152–62. doi:10.1002/bies.10226. PMID 12539241. S2CID 21364125.
Wang X, Lee G, Liebhaber SA, Cooke NE (1992). "Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc". J. Biol. Chem. 267 (13): 9176–84. doi:10.1016/S0021-9258(19)50405-7. PMID 1374386.
Wang X, Ray K, Szpirer J, et al. (1992). "Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism". Genomics. 14 (2): 391–7. doi:10.1016/S0888-7543(05)80231-9. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/94704. PMID 1385304.
Feuerstein R, Wang X, Song D, et al. (1994). "The LIM/double zinc-finger motif functions as a protein dimerization domain". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10655–9. Bibcode:1994PNAS...9110655F. doi:10.1073/pnas.91.22.10655. PMC 45080. PMID 7938009.
Dubé JY, Chapdelaine P, Trahan PL, et al. (1998). "Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate". Arch. Androl. 40 (2): 109–15. doi:10.3109/01485019808987933. PMID 9507743.
Harper BD, Beckerle MC, Pomiès P (2001). "Fine mapping of the alpha-actinin binding site within cysteine-rich protein". Biochem. J. 350 Pt 1 (Pt 1): 269–74. doi:10.1042/0264-6021:3500269. PMC 1221251. PMID 10926853.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Hirasawa Y, Arai M, Imazeki F, et al. (2007). "Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma". Oncology. 71 (1–2): 77–85. doi:10.1159/000100475. PMID 17341888. S2CID 40174270.
Wang Q, Williamson M, Bott S, et al. (2007). "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer". Oncogene. 26 (45): 6560–5. doi:10.1038/sj.onc.1210472. PMID 17486081. S2CID 19222997.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159176 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026421 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2115670-5] Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.

[pmid9925910-6] Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910. S2CID 28018584.

[entrez-7] "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

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