CRLF3

CRLF3
Identifiers
Aliases	CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDs	OMIM: 614853; MGI: 1860086; HomoloGene: 9327; GeneCards: CRLF3; OMA:CRLF3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,824,692 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	79,971,817 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; mononuclear cell; ; monocyte; ; bone marrow; ; blood; ; lymph node; ; epithelium of nasopharynx; ; thymus; ; bone marrow cell; ; mucosa of sigmoid colon;
	Top expressed in
	neural layer of retina; ; granulocyte; ; spleen; ; blood; ; mesenteric lymph nodes; ; thymus; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell; ; bone marrow; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; DNA binding;
Cellular component	plasma membrane; cytoplasm; cytosol; nucleus;
Biological process	negative regulation of cell growth; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of receptor signaling pathway via JAK-STAT; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51379
	54394
	ENSG00000176390
	ENSMUSG00000017561
	Q8IUI8
	Q9Z2L7
	NM_015986
	NM_001277106; NM_018776
	NP_057070
	NP_001264035; NP_061246
	Wikidata
View/Edit Human	View/Edit Mouse

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.⁵

Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.⁶

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.⁷⁸

References

GRCh38: Ensembl release 89: ENSG00000176390 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000017561 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: cytokine receptor-like factor 3".
Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.
Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.
Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. Bibcode:2007BMCEE...7..120L. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.

External links

Human CRLF3 genome location and CRLF3 gene details page in the UCSC Genome Browser.

Further reading

Visser R, Koelma N, Vijfhuizen L, van der Wielen MJ, Kant SG, Breuning MH, et al. (February 2009). "RNF135 mutations are not present in patients with Sotos syndrome-like features". American Journal of Medical Genetics. Part A. 149A (4): 806–8. doi:10.1002/ajmg.a.32694. PMID 19291764. S2CID 10349510.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, et al. (May 2008). "Many sequence variants affecting diversity of adult human height". Nature Genetics. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, et al. (June 2010). "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature". BMC Medical Genetics. 11 96. doi:10.1186/1471-2350-11-96. PMC 2894790. PMID 20546612.
Yang F, Xu YP, Li J, Duan SS, Fu YJ, Zhang Y, et al. (November 2009). "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression". The International Journal of Biochemistry & Cell Biology. 41 (11): 2240–50. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, et al. (July 2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genetics. 6 (7) e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, et al. (August 2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nature Genetics. 39 (8): 963–5. doi:10.1038/ng2083. hdl:2381/22044. PMID 17632510. S2CID 35797973.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176390 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017561 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: cytokine receptor-like factor 3".

[6] Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.

[7] Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.

[8] Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. Bibcode:2007BMCEE...7..120L. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.

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