Article · Wikipedia archive · Last revised Jun 21, 2026

Creatine methyl ester

Creatine methyl ester is the methyl ester derivative of the amino acid creatine. It can be prepared by the esterification of creatine with methanol.

Last revised
Jun 21, 2026
Read time
≈ 1 min
Length
181 w
Citations
2
Source
Creatine methyl ester
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Names
IUPAC name
Methyl N-(aminoiminomethyl)-N-methylglycine
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C5H11N3O2/c1-8(5(6)7)3-4(9)10-2/h3H2,1-2H3,(H3,6,7) checkY
    Key: JQIVVNGNZVUVJC-UHFFFAOYSA-N checkY
  • InChI=1/C5H11N3O2/c1-8(5(6)7)3-4(9)10-2/h3H2,1-2H3,(H3,6,7)
    Key: JQIVVNGNZVUVJC-UHFFFAOYAK
  • NC(N(C)CC(OC)=O)=N
  • O=C(OC)CN(C(=[N@H])N)C
Properties
C5H11N3O2
Molar mass 145.162 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Creatine methyl ester is the methyl ester derivative of the amino acid creatine. It can be prepared by the esterification of creatine with methanol. 1

By undergoing an esterification process with methanol, this compound seeks to enhance creatine's absorption rate in the body. Creatine esters, like creatine methyl ester, have been studied for their potential to improve bioavailability when compared to standard creatine monohydrate.2

See also

See also

References

References

  1. Feng, Liang; Hu, Jiwen; Liu, Zhilei; Zhao, Fabao; Liu, Guojun (June 2007). "Preparation and properties of optically active poly(N-methacryloyl l-leucine methyl ester)". Polymer. 48 (13): 3616–3623. doi:10.1016/j.polymer.2007.04.064. ISSN 0032-3861.
  2. "Creatine Methyl Ester". combatcreatine.com. Retrieved 2024-11-10.