CPSF7

CPSF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3N9U
Identifiers
Aliases	CPSF7, CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDs	MGI: 1917826; HomoloGene: 11731; GeneCards: CPSF7; OMA:CPSF7 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,430,031 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,525,017 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of uterus; ; left ovary; ; canal of the cervix; ; right ovary; ; ventricular zone; ; gastric mucosa;
	Top expressed in
	neural layer of retina; ; mesenteric lymph nodes; ; ventricular zone; ; thymus; ; superior surface of tongue; ; genital tubercle; ; median eminence; ; paraventricular nucleus of hypothalamus; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding;
Cellular component	membrane; nucleus; nucleoplasm; mRNA cleavage factor complex; cytoplasm; mRNA cleavage and polyadenylation specificity factor complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; protein tetramerization; protein heterotetramerization; pre-mRNA cleavage required for polyadenylation; mRNA alternative polyadenylation; messenger ribonucleoprotein complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	79869
	269061
	ENSG00000149532
	ENSMUSG00000034820
	Q8N684
	Q8BTV2
	NM_001136040; NM_001142565; NM_024811
	NM_001164272; NM_172302; NM_001362450
	NP_001129512; NP_001136037; NP_079087
	NP_001157744; NP_758506; NP_001349379
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.⁵⁶

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. ⁷ CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

GRCh38: Ensembl release 89: ENSG00000149532 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034820 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
"Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

Further reading

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Rüegsegger U, Beyer K, Keller W (March 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149532 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034820 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".

[Hardy-7] Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

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