+ SAM
+ 2 NADPH
| Corydaline synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.147 | ||||||||
| CAS no. | 155807-67-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Corydaline synthase (EC 2.1.1.147) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which palmatine is converted to its corydaline. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The reaction also requires nicotinamide adenine dinucleotide phosphate (NADPH). The enzyme was characterised from Corydalis cava.1
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.2
References
References
- Rueffer M, Bauer W, Zenk MH (1994). "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro". Can. J. Chem. 72 (1): 170–175. Bibcode:1994CaJCh..72..170R. doi:10.1139/v94-026.
- Enzyme 2.1.1.147 at KEGG Pathway Database.