CNOT3

CNOT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4C0G, 5FU6, 5FU7
Identifiers
Aliases	CNOT3, LENG2, NOT3, NOT3H, CCR4-NOT transcription complex subunit 3, IDDSADF
External IDs	OMIM: 604910; MGI: 2385261; HomoloGene: 133900; GeneCards: CNOT3; OMA:CNOT3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,155,681 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,661,109 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; pituitary gland; ; granulocyte; ; right uterine tube; ; anterior pituitary; ; right hemisphere of cerebellum; ; ventricular zone; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; blood;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; granulocyte; ; ventricular zone; ; yolk sac; ; neural layer of retina; ; lip; ; hand; ; Rostral migratory stream;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; CCR4-NOT complex; cytosol; P-body; nucleus; CCR4-NOT core complex;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; multicellular organism development; gene silencing; negative regulation of translation; regulation of stem cell population maintenance; regulation of transcription, DNA-templated; trophectodermal cell differentiation; regulation of translation; transcription, DNA-templated; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4849
	232791
ENSG00000088038; ENSG00000277600; ENSG00000277114; ENSG00000274616; ENSG00000275979;
	ENSG00000277615; ENSG00000276082; ENSG00000274176; ENSG00000274941; ENSG00000273943
	ENSMUSG00000035632
	O75175
	Q8K0V4
	NM_014516
	NM_146176
	NP_055331
	NP_666288
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene.⁵⁶⁷ It is a subunit of the CCR4-Not deadenylase complex.

Interactions

CNOT3 has been shown to interact with CNOT8.⁵

References

ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 GRCh38: Ensembl release 89: ENSG00000088038, ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035632 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
"Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

External links

Human CNOT3 genome location and CNOT3 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 GRCh38: Ensembl release 89: ENSG00000088038, ENSG00000277600, ENSG00000277114, ENSG00000274616, ENSG00000275979, ENSG00000277615, ENSG00000276082, ENSG00000274176, ENSG00000274941, ENSG00000273943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035632 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637334-5] Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

[pmid9734811-6] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[entrez-7] "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

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Interactions

References

Further reading

External links