Article · Wikipedia archive · Last revised Aug 10, 2026

Clogestone acetate

Clogestone acetate is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never marketed. It is the diacetate ester of clogestone, which, similarly was never marketed. Clogestone acetate produces chlormadinone acetate as an active metabolite.

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Clogestone acetate
Clinical data
Other namesChlormadinol acetate; AY-11440; 3β,17α-Diacetoxy-6-chloropregna-4,6-diene-20-one
Drug classProgestogen; Progestogen ester
Identifiers
  • (1S,2R,5S,10R,11S,14R,15S)-14-acetyl-5-(acetyloxy)-8-chloro-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-6,8-dien-14-yl acetate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H33ClO5
Molar mass448.98 g·mol−1
3D model (JSmol)
  • CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(CCC34C)OC(=O)C)Cl)C)OC(=O)C
  • InChI=1S/C25H33ClO5/c1-14(27)25(31-16(3)29)11-8-20-18-13-22(26)21-12-17(30-15(2)28)6-9-23(21,4)19(18)7-10-24(20,25)5/h12-13,17-20H,6-11H2,1-5H3/t17-,18+,19-,20-,23+,24-,25-/m0/s1
  • Key:KSCZWFXQKITHSL-OKCNGXCSSA-N

Clogestone acetate (USANTooltip United States Adopted Name; developmental code AY-11440; also known as chlormadinol acetate or 3β,17α-diacetoxy-6-chloropregna-4,6-diene-20-one1) is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never marketed.2345 It is the diacetate ester of clogestone, which, similarly was never marketed.2 Clogestone acetate produces chlormadinone acetate as an active metabolite.6

See also

See also

References

References

  1. Litwack G (2 December 2012). Biochemical Actions of Hormones. Elsevier. pp. 323–. ISBN 978-0-323-15189-4.
  2. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 297–. ISBN 978-1-4757-2085-3.
  3. Hawkins DR, Elder MG (22 October 2013). Human Fertility Control: Theory and Practice. Elsevier Science. pp. 3–. ISBN 978-1-4831-6361-1.
  4. Harper MJ (8 March 2013). "Contraception — retrospect and prospect". Progress in Drug Research, vol. 21. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques. Vol. 21. Birkhäuser. pp. 293–407. doi:10.1007/978-3-0348-7098-6_4. ISBN 978-3-0348-7098-6. PMID 339271.
  5. Hinselmann M, Jürgensen O, Hasselblatt I, Otten U, Prinz W, Taubert HD (August 1970). "[Clogestone acetate, a new orally effective progestagen]". Archiv für Gynäkologie (in German). 209 (2): 136–148. doi:10.1007/BF00668180. PMID 5537778.
  6. Stern MD, Givner ML (April 1975). "Measurement of serum clogestone acetate (AY-11,440) by a radioreceptor assay: a practical approach to the quantitative determination of synthetic progestins". The Journal of Clinical Endocrinology and Metabolism. 40 (4): 728–731. doi:10.1210/jcem-40-4-728. PMID 1127082.