CLDN9

CLDN9
Identifiers
Aliases	CLDN9, claudin 9, DFNB116
External IDs	OMIM: 615799; MGI: 1913100; HomoloGene: 10656; GeneCards: CLDN9; OMA:CLDN9 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,014,505 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,903,000 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; pituitary gland; ; anterior pituitary; ; testicle; ; blood; ; body of pancreas; ; right uterine tube; ; right lobe of liver; ; C1 segment; ; apex of heart;
	Top expressed in
	vestibular sensory epithelium; ; vestibular membrane of cochlear duct; ; olfactory epithelium; ; stria vascularis; ; pituitary gland; ; lumbar spinal ganglion; ; utricle; ; Epithelium of choroid plexus; ; median eminence; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding; protein binding; virus receptor activity;
Cellular component	integral component of membrane; membrane; bicellular tight junction; cell junction; intracellular membrane-bounded organelle; plasma membrane;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; viral process; cell-cell junction organization; viral entry into host cell; tight junction organization;
	Sources:Amigo / QuickGO
Orthologs
	9080
	56863
	ENSG00000213937
	ENSMUSG00000066720
	O95484
	Q9Z0S7
	NM_020982
	NM_020293
	NP_066192
	NP_064689
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene.⁵⁶⁷ It belongs to the group of claudins.

This gene is expressed in the inner ear, olfactory epithelium, and anterior pituitary gland ⁸ and is involved in hearing.⁹¹⁰¹¹

References

GRCh38: Ensembl release 89: ENSG00000213937 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066720 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.
"Entrez Gene: CLDN9 claudin 9".
Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes tight junctions of folliclo-stellate cells in the anterior pituitary gland". Scientific Reports. 11 (1): 21642. Bibcode:2021NatSR..1121642H. doi:10.1038/s41598-021-01004-z. PMC 8568902. PMID 34737342.
Gene discovery reveals a critical protein's function in hearing
Nakano Y, Kim SH, Kim HM, Sanneman JD, Zhang Y, Smith RJ, Marcus DC, Wangemann P, Nessler RA, Bánfi B (Aug 2009). "A claudin-9-based ion permeability barrier is essential for hearing". PLOS Genetics. 5 (8) e1000610. doi:10.1371/journal.pgen.1000610. PMC 2720454. PMID 19696885.
Sineni CJ, Yildirim-Baylan M, Guo S, Camarena V, Wang G, Tokgoz-Yilmaz S, Duman D, Bademci G, Tekin M (Oct 2019). "A truncating CLDN9 variant if associated with autosomal recessive nonsyndromic hearing loss". Human Genetics. 138 (10): 1071–1075. doi:10.1007/s00439-019-02037-1. PMC 6745279. PMID 31175426.

External links

Human CLDN9 genome location and CLDN9 gene details page in the UCSC Genome Browser.

Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi:10.1681/ASN.V134875. PMID 11912246.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.
Kitajiri SI, Furuse M, Morita K, et al. (2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear". Hear. Res. 187 (1–2): 25–34. doi:10.1016/S0378-5955(03)00338-1. PMID 14698084. S2CID 31183039.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zheng A, Yuan F, Li Y, et al. (2007). "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus". J. Virol. 81 (22): 12465–71. doi:10.1128/JVI.01457-07. PMC 2169001. PMID 17804490.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213937 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066720 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9441748-5] Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.

[pmid18234789-6] Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus". J Virol. 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.

[entrez-7] "Entrez Gene: CLDN9 claudin 9".

[8] Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H (Nov 2021). "Claudin-9 constitutes tight junctions of folliclo-stellate cells in the anterior pituitary gland". Scientific Reports. 11 (1): 21642. Bibcode:2021NatSR..1121642H. doi:10.1038/s41598-021-01004-z. PMC 8568902. PMID 34737342.

[9] Gene discovery reveals a critical protein's function in hearing

[10] Nakano Y, Kim SH, Kim HM, Sanneman JD, Zhang Y, Smith RJ, Marcus DC, Wangemann P, Nessler RA, Bánfi B (Aug 2009). "A claudin-9-based ion permeability barrier is essential for hearing". PLOS Genetics. 5 (8) e1000610. doi:10.1371/journal.pgen.1000610. PMC 2720454. PMID 19696885.

[11] Sineni CJ, Yildirim-Baylan M, Guo S, Camarena V, Wang G, Tokgoz-Yilmaz S, Duman D, Bademci G, Tekin M (Oct 2019). "A truncating CLDN9 variant if associated with autosomal recessive nonsyndromic hearing loss". Human Genetics. 138 (10): 1071–1075. doi:10.1007/s00439-019-02037-1. PMC 6745279. PMID 31175426.

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