CLDN22

CLDN22
Identifiers
Aliases	CLDN22, CLDN21, claudin 22
External IDs	MGI: 1922927; HomoloGene: 129823; GeneCards: CLDN22; OMA:CLDN22 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	183,320,276 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	48,278,511 bp
RNA expression pattern
	Top expressed in
	testicle; ; olfactory zone of nasal mucosa; ; minor salivary glands; ; gonad; ; granulocyte; ; right lobe of liver; ; apex of heart; ; primary visual cortex; ; endometrium; ; ventricular zone;
	Top expressed in
	parotid gland; ; sciatic nerve; ; otolith organ; ; utricle; ; lacrimal gland; ; vestibular sensory epithelium; ; blastocyst; ; morula; ; lumbar spinal ganglion; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; identical protein binding;
Cellular component	plasma membrane; integral component of membrane; cell junction; membrane; bicellular tight junction;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	53842
	75677
	ENSG00000177300
	ENSMUSG00000038064
	Q8N7P3
	Q9D7U6
	NM_001111319
	NM_029383
	NP_001104789
	NP_083659
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene.⁵ It belongs to the group of claudins.

References

GRCh38: Ensembl release 89: ENSG00000177300 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038064 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CLDN22 claudin 22".

External links

Human CLDN22 genome location and CLDN22 gene details page in the UCSC Genome Browser.

Further reading

González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177300 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038064 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN22 claudin 22".

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