CLDN20

CLDN20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YYX
Identifiers
Aliases	CLDN20, claudin 20
External IDs	MGI: 3646757; HomoloGene: 47972; GeneCards: CLDN20; OMA:CLDN20 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	155,276,548 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	3,583,484 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; testicle; ; tendon; ; stromal cell of endometrium; ; tibial nerve; ; epithelium of colon; ; Achilles tendon; ; right adrenal cortex; ; left adrenal gland; ; smooth muscle tissue;
	Top expressed in
	embryo; ; secondary oocyte; ; zygote; ; granulocyte; ; bone marrow; ; primary oocyte; ; ganglionic eminence; ; olfactory bulb; ; striatum of neuraxis; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; membrane; bicellular tight junction;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	49861
	621628
	ENSG00000171217
	ENSMUSG00000091530
	P56880
	G5E8X0
	NM_001001346
	NM_001101560
	NP_001001346
	NP_001095030
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-20 is a protein that in humans is encoded by the CLDN20 gene.⁵⁶ It belongs to the group of claudins.

References

GRCh38: Ensembl release 89: ENSG00000171217 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000091530 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hewitt KJ, Agarwal R, Morin PJ (Aug 2006). "The claudin gene family: expression in normal and neoplastic tissues". BMC Cancer. 6: 186. doi:10.1186/1471-2407-6-186. PMC 1538620. PMID 16836752.
"Entrez Gene: CLDN20 claudin 20".

External links

Human CLDN20 genome location and CLDN20 gene details page in the UCSC Genome Browser.

Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Berg M, Geisel A, Necheles H (1975). "The influence of carbenoxolone on steroid-induced ulcer and mucus secretion in the rat". The American Journal of Digestive Diseases. 20 (2): 134–7. doi:10.1007/BF01072339. PMID 1124737. S2CID 29907180.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–59. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171217 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16836752-5] Hewitt KJ, Agarwal R, Morin PJ (Aug 2006). "The claudin gene family: expression in normal and neoplastic tissues". BMC Cancer. 6: 186. doi:10.1186/1471-2407-6-186. PMC 1538620. PMID 16836752.

[entrez-6] "Entrez Gene: CLDN20 claudin 20".

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