Article · Wikipedia archive · Last revised Jul 28, 2026

Chlorphenoxamine

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine.

Last revised
Jul 28, 2026
Read time
≈ 1 min
Length
170 w
Citations
3
Source
Wikipedia ↗
Chlorphenoxamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, topical
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
MetabolismLikely liver
Excretionkidney
Identifiers
  • {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.115.538
Chemical and physical data
FormulaC18H22ClNO
Molar mass303.83 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C
  • InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 checkY
  • Key:KKHPNPMTPORSQE-UHFFFAOYSA-N checkY
 X markNcheckY (what is this?)  (verify)

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic1 and antiparkinsonian2 agent. It is an analog of diphenhydramine.3

References

References

  1. Bazex A, Dupre A, Christol B (1963). "[Trial treatment of urticaria with chlorphenoxamine]". Clinique. 58: 447–50. PMID 13967113.
  2. Uldall PR, Walton JN, Newell DJ (June 1961). "Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial". British Medical Journal. 1 (5240): 1649–52. doi:10.1136/bmj.1.5240.1649. PMC 1954253. PMID 13779077.
  3. Arnold H, Brock N, Kuhas E, Lorenz D (January 1954). "Beitrag Zur Wirkung Von Antihistamin-Substanzen. 1. Chemische Konstitution Und Pharmakologische Wirkung in Der Gruppe Der Basischen Benzhydrylaether" [Contribution to the Effect Of Antihistamine Substances. 1. Chemical constitution and pharmacological activity in the group of basic benzhydrylethers]. Arzneimittel-Forschung [Drug Research] (in German). 4 (3): 189–94. PMID 13159698.