Article · Wikipedia archive · Last revised Jul 28, 2026

Chicken ovalbumin upstream promoter-transcription factor

The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively.

Last revised
Jul 28, 2026
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≈ 1 min
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Wikipedia ↗
nuclear receptor subfamily 2, group F, member 1
Identifiers
SymbolNR2F1
Alt. symbolsERBAL3, TFCOUP1, EAR-3, COUP-TFI, TCFCOUP1, SVP44
NCBI gene7025
HGNC7975
OMIM132890
RefSeqNM_005654
UniProtP10589
Other data
LocusChr. 5 q14
Search for
StructuresSwiss-model
DomainsInterPro
nuclear receptor subfamily 2, group F, member 2
Identifiers
SymbolNR2F2
Alt. symbolsARP1, TFCOUP2, COUP-TFII, COUPTFB, SVP40
NCBI gene7026
HGNC7976
OMIM107773
RefSeqNM_021005
UniProtP24468
Other data
LocusChr. 15 q26
Search for
StructuresSwiss-model
DomainsInterPro

The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors.1 There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively.

COUP-TFs play critical roles in the development of organisms.2

References

References

  1. Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
  2. Park JI, Tsai SY, Tsai MJ (2003). "Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions" (PDF). The Keio Journal of Medicine. 52 (3): 174–81. doi:10.2302/kjm.52.174. PMID 14529150.
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