Article · Wikipedia archive · Last revised Jul 16, 2026

CHF-1024

CHF-1024, also known as 5,6-dihydroxy-2-methylaminotetralin, is a dopamine D2 receptor agonist and α2-adrenergic receptor agonist of the 2-aminotetralin family. It is a cyclized phenethylamine analogue of the neurotransmitter dopamine. The drug is the active form of nolomirole (CHF-1035), a prodrug of CHF-1024 and the N,N-diisobutyryl diester of the compound. Nolomirole was investigated for the treatment of heart failure but was never marketed.

Last revised
Jul 16, 2026
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≈ 1 min
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CHF-1024
Clinical data
Other namesCHF1024; 5,6-Dihydroxy-2-methylaminotetralin
Drug classDopamine D2 recpetor agonist; α2-Adrenergic receptor agonist
ATC code
  • None
Identifiers
  • 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • CNC1CCC2=C(C1)C=CC(=C2O)O
  • InChI=1S/C11H15NO2/c1-12-8-3-4-9-7(6-8)2-5-10(13)11(9)14/h2,5,8,12-14H,3-4,6H2,1H3
  • Key:BHDFPNRSDABMPW-UHFFFAOYSA-N

CHF-1024, also known as 5,6-dihydroxy-2-methylaminotetralin, is a dopamine D2 receptor agonist and α2-adrenergic receptor agonist of the 2-aminotetralin family.12 It is a cyclized phenethylamine analogue of the neurotransmitter dopamine.1 The drug is the active form of nolomirole (CHF-1035), a prodrug of CHF-1024 and the N,N-diisobutyryl diester of the compound.12 Nolomirole was investigated for the treatment of heart failure but was never marketed.12

See also

See also

References

References

  1. Mealy NE, Leeson PA, Bayes M, Castaner J (2001). "Nolomirole Hydrochloride". Drugs of the Future. 26 (11): 1046. doi:10.1358/dof.2001.026.11.642071. Retrieved 19 June 2025.
  2. Tang WH, Francis GS (November 2003). "Novel pharmacological treatments for heart failure". Expert Opinion on Investigational Drugs. 12 (11): 1791–1801. doi:10.1517/13543784.12.11.1791. PMID 14585055.