CDC42BPA

CDC42BPA
Identifiers
Aliases	CDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDs	OMIM: 603412; MGI: 2441841; HomoloGene: 55765; GeneCards: CDC42BPA; OMA:CDC42BPA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	227,318,492 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	179,993,168 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; pylorus; ; tibia; ; lateral nuclear group of thalamus; ; secondary oocyte; ; external globus pallidus; ; pars reticulata; ; renal medulla; ; Brodmann area 23; ; corpus callosum;
	Top expressed in
	zygote; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; genital tubercle; ; central gray substance of midbrain; ; neural layer of retina; ; medial geniculate nucleus; ; nucleus of stria terminalis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding; magnesium ion binding; metal ion binding; identical protein binding; kinase activity;
Cellular component	cytoplasm; actomyosin; extracellular exosome; cell leading edge; cell-cell junction; lamellipodium; cell projection; cytoskeleton;
Biological process	protein phosphorylation; actomyosin structure organization; intracellular signal transduction; cell migration; phosphorylation; actin cytoskeleton reorganization; actin cytoskeleton organization; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8476
	226751
	ENSG00000143776
	ENSMUSG00000026490
	Q5VT25
	Q3UU96
NM_003607; NM_014826; NM_001366010; NM_001366011; NM_001366019;
	NM_001387550; NM_001394014
NM_001033285; NM_001346804; NM_001346805; NM_001359541; NM_001359542;
	NM_001359543; NM_001359544; NM_001359545; NM_001359546; NM_001359547; NM_001359548; NM_001359549
	NP_003598; NP_055641; NP_001352939; NP_001352940; NP_001352948
NP_001028457; NP_001333733; NP_001333734; NP_001346470; NP_001346471;
	NP_001346472; NP_001346473; NP_001346474; NP_001346475; NP_001346476; NP_001346477; NP_001346478
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.⁵

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.⁵

References

GRCh38: Ensembl release 89: ENSG00000143776 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026490 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

External links

Human CDC42BPA genome location and CDC42BPA gene details page in the UCSC Genome Browser.

Further reading

Zhao Y, Loyer P, Li H, et al. (1997). "Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases". J. Biol. Chem. 272 (15): 10013–20. doi:10.1074/jbc.272.15.10013. PMID 9092543.
Leung T, Chen XQ, Tan I, et al. (1998). "Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization". Mol. Cell. Biol. 18 (1): 130–40. doi:10.1128/mcb.18.1.130. PMC 121465. PMID 9418861.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Moncrieff CL, Bailey ME, Morrison N, Johnson KJ (1999). "Cloning and chromosomal localization of human Cdc42-binding protein kinase beta". Genomics. 57 (2): 297–300. doi:10.1006/geno.1999.5769. PMID 10198171.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.
Ohashi K, Nagata K, Maekawa M, et al. (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop". J. Biol. Chem. 275 (5): 3577–82. doi:10.1074/jbc.275.5.3577. PMID 10652353.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Nakamura N, Oshiro N, Fukata Y, et al. (2000). "Phosphorylation of ERM proteins at filopodia induced by Cdc42". Genes Cells. 5 (7): 571–81. doi:10.1046/j.1365-2443.2000.00348.x. PMID 10947843. S2CID 10022990.
Lam LT, Pham YC, Nguyen TM, Morris GE (2000). "Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart". Hum. Mol. Genet. 9 (14): 2167–73. doi:10.1093/hmg/9.14.2167. PMID 10958655.
Tan I, Seow KT, Lim L, Leung T (2001). "Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha". Mol. Cell. Biol. 21 (8): 2767–78. doi:10.1128/MCB.21.8.2767-2778.2001. PMC 86907. PMID 11283256.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Dong JM, Leung T, Manser E, Lim L (2003). "Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation". Eur. J. Cell Biol. 81 (4): 231–42. doi:10.1078/0171-9335-00238. PMID 12018391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tan I, Cheong A, Lim L, Leung T (2003). "Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity". Gene. 304: 107–15. doi:10.1016/S0378-1119(02)01185-X. PMID 12568720.
Wilkinson S, Paterson HF, Marshall CJ (2005). "Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion". Nat. Cell Biol. 7 (3): 255–61. doi:10.1038/ncb1230. PMID 15723050. S2CID 34732713.
Cmejla R, Petrak J, Cmejlova J (2006). "A novel iron responsive element in the 3'UTR of human MRCKalpha". Biochem. Biophys. Res. Commun. 341 (1): 158–66. doi:10.1016/j.bbrc.2005.12.155. PMID 16412980.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lefort K, Mandinova A, Ostano P, et al. (2007). "Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases". Genes Dev. 21 (5): 562–77. doi:10.1101/gad.1484707. PMC 1820898. PMID 17344417.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143776 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026490 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

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