Cassavetes (Greek: Κασσαβέτης) is a Greek surname. Notable people with the surname include:
- John Cassavetes (1929–1989), Greek-American independent film director
- Katherine Cassavetes (1906–1983), his mother, an actress
- Nick Cassavetes (born 1959), his son, an actor and director
- Alexandra Cassavetes (born 1965), his daughter, an actress and director
- Zoe Cassavetes (born 1970), his daughter, a director