CALCOCO2

CALCOCO2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3VVV, 3VVW, 4GXL, 4HAN, 2MXP, 4XKL
Identifiers
Aliases	CALCOCO2, NDP52, calcium binding and coiled-coil domain 2
External IDs	OMIM: 604587; HomoloGene: 31339; GeneCards: CALCOCO2; OMA:CALCOCO2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,866,522 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastric mucosa; ; right lung; ; epithelium of colon; ; sural nerve; ; left testis; ; right testis; ; rectum; ; popliteal artery; ; tibial arteries;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; autophagosome; autophagosome membrane; cytoskeleton; membrane; cytoplasmic vesicle; nucleus; intracellular membrane-bounded organelle; cytosol;
Biological process	autophagy; viral process; positive regulation of autophagosome maturation; response to interferon-gamma; xenophagy;
	Sources:Amigo / QuickGO
Orthologs
	10241
	n/a
	ENSG00000136436
	n/a
	Q13137
	n/a
	NM_001261390; NM_001261391; NM_001261393; NM_001261395; NM_005831
	n/a
	NP_001248319; NP_001248320; NP_001248322; NP_001248324; NP_005822
	n/a
	Wikidata
View/Edit Human

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.³⁴

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles.⁴

CALCOCO2 is an autophagy receptor, and loss of CALCOCO2 in human beta cells has been linked to autophagy-mediated altered insulin granule homeostasis. Thus, mutations in CALCOCO2 have been linked to type 2 diabetes risk.⁵

Interactions

CALCOCO2 has been shown to interact with CVB3 3C.⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000136436 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Korioth F, Gieffers C, Maul GG, Frey J (July 1995). "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment". The Journal of Cell Biology. 130 (1): 1–13. doi:10.1083/jcb.130.1.1. PMC 2120522. PMID 7540613.
"Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2".
Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. (December 2022). "A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk". Nature Genetics. 55 (1): 54–65. doi:10.1038/s41588-022-01261-2. PMC 9839450. PMID 36543916.
Yasir Mohamud, Junyan Qu, Yuan Chao Xue, Huitao Liu, Haoyu Deng, Honglin Luo (28 August 2018). "CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation". Cell Death & Differentiation. 26 (6): 1062–1076. doi:10.1038/S41418-018-0185-5. ISSN 1350-9047. PMC 6748094. PMID 30154446. Wikidata Q59353698.
Yasir Mohamud, Wikidata Q138763465

External links

CALCOCO2 human gene location in the UCSC Genome Browser.
CALCOCO2 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136436 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7540613-3] Korioth F, Gieffers C, Maul GG, Frey J (July 1995). "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment". The Journal of Cell Biology. 130 (1): 1–13. doi:10.1083/jcb.130.1.1. PMC 2120522. PMID 7540613.

[entrez-4] "Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2".

[5] Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. (December 2022). "A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk". Nature Genetics. 55 (1): 54–65. doi:10.1038/s41588-022-01261-2. PMC 9839450. PMID 36543916.

[6] Yasir Mohamud, Junyan Qu, Yuan Chao Xue, Huitao Liu, Haoyu Deng, Honglin Luo (28 August 2018). "CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation". Cell Death & Differentiation. 26 (6): 1062–1076. doi:10.1038/S41418-018-0185-5. ISSN 1350-9047. PMC 6748094. PMID 30154446. Wikidata Q59353698.

[7] Yasir Mohamud, Wikidata Q138763465

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Interactions

References

Further reading

External links