Article · Wikipedia archive · Last revised Jul 25, 2026

Cafedrine

Cafedrine, sold under the brand name Akrinor among others, is a chemical linkage of norephedrine and theophylline and is a cardiac stimulant and antihypotensive agent used to increase blood pressure in people with hypotension. It has been marketed in Europe, South Africa, and Indonesia.

Last revised
Jul 25, 2026
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≈ 1 min
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Wikipedia ↗
Cafedrine
Clinical data
Trade namesAkrinor, Bifort, Praxinor
Other namesCaphedrine; Cafedrin; Caphedrin; Kafedrin; Norephedrino-ethyltheophylline; 7-(2-(β-Hydroxy-α-methylphen-ethylamino)ethyl)theophylline
ATC code
Identifiers
  • (RS)-7-[2-[(1-hydroxy-1-phenylpropan-2-yl)amino]ethyl]-1,3-dimethylpurine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H23N5O3
Molar mass357.414 g·mol−1
3D model (JSmol)
  • C(CN[C@H]([C@H](O)C1=CC=CC=C1)C)N2C3=C(N(C)C(=O)N(C)C3=O)N=C2
  • InChI=1S/C18H23N5O3/c1-12(15(24)13-7-5-4-6-8-13)19-9-10-23-11-20-16-14(23)17(25)22(3)18(26)21(16)2/h4-8,11-12,15,19,24H,9-10H2,1-3H3/t12-,15-/m0/s1 checkY
  • Key:UJSKUDDDPKGBJY-WFASDCNBSA-N checkY
 X markNcheckY (what is this?)  (verify)

Cafedrine (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name), sold under the brand name Akrinor among others, is a chemical linkage of norephedrine and theophylline and is a cardiac stimulant and antihypotensive agent used to increase blood pressure in people with hypotension.1234 It has been marketed in Europe, South Africa, and Indonesia.45

There has been concern about cafedrine as a potential performance-enhancing drug and doping agent in sports.6

See also

See also

References

References

  1. Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 205. ISBN 978-1-4757-2085-3. Retrieved 29 August 2024.
  2. Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. 2013. p. 785. ISBN 978-0-8155-1856-3. Retrieved 29 August 2024.
  3. Morton IK, Hall JM (1999). "Calcitonin gene-related peptide receptor antagonist". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 59. ISBN 9789401144391.
  4. Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 157. ISBN 978-3-88763-075-1. Retrieved 29 August 2024.
  5. "Cafedrine". Drugs.com. Archived from the original on 6 January 2018. Retrieved 29 August 2024.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  6. Wilson W, Derse E (2001). Doping in Elite Sport: The Politics of Drugs in the Olympic Movement. Human Kinetics. p. 15. ISBN 978-0-7360-0329-2. Retrieved 29 August 2024.