BRD9

BRD9
Identifiers
Aliases	BRD9, LAVS3040, PRO9856, bromodomain containing 9
External IDs	OMIM: 618465; MGI: 2145317; HomoloGene: 82462; GeneCards: BRD9; OMA:BRD9 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HME, 4NQN, 4UIT, 4UIU, 4UIV, 4UIW, 4XY8, 4Z6H, 4Z6I, 4YY4, 4YY6, 4YYD, 4YYG, 4YYH, 4YYI, 4YYJ, 4YYK, 5E9V, 5F1H, 5F1L, 5F2P, 5F25, 5EU1, 5IGN, 5JI8
Gene location (Human)
Chr.	Chromosome 5 (human)
End	892,824 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,960,895 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; granulocyte; ; thymus; ; right hemisphere of cerebellum; ; skin of abdomen; ; skin of leg; ; left testis;
	Top expressed in
	primary visual cortex; ; neural layer of retina; ; spermatocyte; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; cumulus cell; ; ventricular zone; ; hand; ; superior frontal gyrus; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; lysine-acetylated histone binding; nucleic acid binding;
Cellular component	cellular component; SWI/SNF complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; biological process; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	65980
	105246
	ENSG00000028310
	ENSMUSG00000057649
	Q9H8M2
	Q3UQU0
	NM_001009877; NM_023924; NM_001317951
	NM_001024508; NM_001308041; NM_001378947; NM_001378948
NP_001009877; NP_001304880; NP_076413; NP_001362790; NP_001362791;
	NP_001362792; NP_001362806; NP_001362807; NP_001362808
	NP_001019679; NP_001294970; NP_001365876; NP_001365877
	Wikidata
View/Edit Human	View/Edit Mouse

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene.⁵

Structure and interaction

BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes.⁶

Role in cancer

The BRD9 gene is frequently present in variable copy number in lung cancer.⁷

Small molecule inhibition

Small molecules capable of binding to the bromodomain of BRD9 have been developed.⁸⁹¹⁰

References

GRCh38: Ensembl release 89: ENSG00000028310 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000057649 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Bromodomain containing 9".
Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, et al. (June 2013). "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy". Nature Genetics. 45 (6): 592–601. doi:10.1038/ng.2628. PMC 3667980. PMID 23644491.
Kang JU, Koo SH, Kwon KC, Park JW, Kim JM (April 2008). "Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer". Cancer Genetics and Cytogenetics. 182 (1): 1–11. doi:10.1016/j.cancergencyto.2007.12.004. PMID 18328944.
Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, et al. (January 2014). "[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains". Journal of Medicinal Chemistry. 57 (2): 462–476. doi:10.1021/jm401568s. PMC 3906316. PMID 24313754.
Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, et al. (May 2015). "LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor". Angewandte Chemie. 54 (21): 6217–6221. Bibcode:2015ACIE...54.6217C. doi:10.1002/anie.201501394. PMC 4449114. PMID 25864491.
Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, et al. (February 2016). "Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition". Journal of Medicinal Chemistry. 59 (4): 1425–1439. doi:10.1021/acs.jmedchem.5b00256. PMC 7354103. PMID 25856009.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000028310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057649 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Bromodomain containing 9".

[6] Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, et al. (June 2013). "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy". Nature Genetics. 45 (6): 592–601. doi:10.1038/ng.2628. PMC 3667980. PMID 23644491.

[7] Kang JU, Koo SH, Kwon KC, Park JW, Kim JM (April 2008). "Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer". Cancer Genetics and Cytogenetics. 182 (1): 1–11. doi:10.1016/j.cancergencyto.2007.12.004. PMID 18328944.

[8] Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, et al. (January 2014). "[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains". Journal of Medicinal Chemistry. 57 (2): 462–476. doi:10.1021/jm401568s. PMC 3906316. PMID 24313754.

[9] Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, et al. (May 2015). "LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor". Angewandte Chemie. 54 (21): 6217–6221. Bibcode:2015ACIE...54.6217C. doi:10.1002/anie.201501394. PMC 4449114. PMID 25864491.

[10] Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, et al. (February 2016). "Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition". Journal of Medicinal Chemistry. 59 (4): 1425–1439. doi:10.1021/acs.jmedchem.5b00256. PMC 7354103. PMID 25856009.

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Structure and interaction

Role in cancer

Small molecule inhibition

See also

References