Article · Wikipedia archive · Last revised Jun 12, 2026

Benzophenone synthase

Benzophenone synthase is an enzyme that catalyzes a chemical reaction which takes one unit of 3-hydroxybenzoyl-CoA and combines this with three units of malonyl-CoA to give the benzophenone, 2,3',4,6-tetrahydroxybenzophenone, as product. Four units of coenzyme A and three of carbon dioxide are byproducts. The enzyme was characterised from the plant Centaurium erythraea. The product is an intermediate in the biosynthesis of xanthones.

Last revised
Jun 12, 2026
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Benzophenone synthase
Identifiers
EC no.2.3.1.151
CAS no.175780-21-9
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Benzophenone synthase (EC 2.3.1.151) is an enzyme that catalyzes a chemical reaction which takes one unit of 3-hydroxybenzoyl-CoA and combines this with three units of malonyl-CoA to give the benzophenone, 2,3',4,6-tetrahydroxybenzophenone, as product. Four units of coenzyme A and three of carbon dioxide are byproducts. The enzyme was characterised from the plant Centaurium erythraea. The product is an intermediate in the biosynthesis of xanthones.1

3-hydroxybenzoyl-CoA
+ 3
 
 
 
3 CO2
Rightward reaction arrow with minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27098205.
2,3',4,6-tetrahydroxybenzophenone
 


This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase.2

References

References

  1. Beerhues L (April 1996). "Benzophenone synthase from cultured cells of Centaurium erythraea". FEBS Letters. 383 (3): 264–6. Bibcode:1996FEBSL.383..264B. doi:10.1016/0014-5793(96)00265-7. PMID 8925910.
  2. Enzyme 2.3.1.151 at KEGG Pathway Database.