ANKRD23

ANKRD23
Identifiers
Aliases	ANKRD23, DARP, MARP3, ankyrin repeat domain 23
External IDs	OMIM: 610736; MGI: 1925571; HomoloGene: 14025; GeneCards: ANKRD23; OMA:ANKRD23 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,857,934 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	36,575,964 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; sural nerve; ; tibialis anterior muscle; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; right uterine tube; ; apex of heart; ; biceps brachii;
	Top expressed in
	quadriceps femoris muscle; ; muscle tissue; ; muscle of thigh; ; skeletal muscle tissue; ; esophagus; ; zone of skin; ; lip; ; heart; ; adrenal gland; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	titin binding;
Cellular component	myofibril; nucleus; intercalated disc; nucleoplasm; actin cytoskeleton; cytosol;
Biological process	response to mechanical stimulus;
	Sources:Amigo / QuickGO
Orthologs
	200539
	78321
	ENSG00000163126
	ENSMUSG00000067653
	Q86SG2
	Q812A3
	NM_144994
	NM_153502; NM_001310521
	NP_659431
	NP_001297450; NP_705722
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.⁵⁶

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.⁶

Interactions

ANKRD23 has been shown to interact with Titin⁷ and MYPN.⁷

References

GRCh38: Ensembl release 89: ENSG00000163126 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000067653 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.
"Entrez Gene: ANKRD23 ankyrin repeat domain 23".
Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.

External links

Human ANKRD23 genome location and ANKRD23 gene details page in the UCSC Genome Browser.

Further reading

Hillier LW; Graves TA; Fulton RS; et al. (2005), "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", Nature, 434 (7034): 724–31, Bibcode:2005Natur.434..724H, doi:10.1038/nature03466, PMID 15815621
Gerhard DS; Wagner L; Feingold EA; et al. (2004), "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", Genome Res., 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334
Nagueh SF; Shah G; Wu Y; et al. (2005), "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy", Circulation, 110 (2): 155–62, doi:10.1161/01.CIR.0000135591.37759.AF, PMID 15238456
Ota T; Suzuki Y; Nishikawa T; et al. (2004), "Complete sequencing and characterization of 21,243 full-length human cDNAs", Nat. Genet., 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039
Miller MK; Bang ML; Witt CC; et al. (2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules", J. Mol. Biol., 333 (5): 951–64, doi:10.1016/j.jmb.2003.09.012, PMID 14583192
Strausberg RL; Feingold EA; Grouse LH; et al. (2003), "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", Proc. Natl. Acad. Sci. U.S.A., 99 (26): 16899–903, Bibcode:2002PNAS...9916899M, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932
Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000), "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", Proc. Natl. Acad. Sci. U.S.A., 97 (7): 3491–6, Bibcode:2000PNAS...97.3491D, doi:10.1073/pnas.97.7.3491, PMC 16267, PMID 10737800

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163126 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067653 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12456686-5] Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.

[entrez-6] "Entrez Gene: ANKRD23 ankyrin repeat domain 23".

[pmid14583192-7] Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.

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