Article · Wikipedia archive · Last revised Jul 22, 2026

Aleph-6

Aleph-6, or ALEPH-6, also known as 4-phenylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is one of the Aleph series of compounds.

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Jul 22, 2026
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Aleph-6
Clinical data
Other namesALEPH-6; DOT-6; 4-Phenylthio-2,5-dimethoxyamphetamine; 2,5-Dimethoxy-4-phenylthioamphetamine; 4-PhS-DMA
Routes of
administration		Oral1
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action"Probably long" (at least 12 hours)1
Identifiers
  • 1-(2,5-dimethoxy-4-phenylsulfanylphenyl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H21NO2S
Molar mass303.42 g·mol−1
3D model (JSmol)
  • CC(CC1=CC(=C(C=C1OC)SC2=CC=CC=C2)OC)N
  • InChI=1S/C17H21NO2S/c1-12(18)9-13-10-16(20-3)17(11-15(13)19-2)21-14-7-5-4-6-8-14/h4-8,10-12H,9,18H2,1-3H3
  • Key:CSOTVYXYZSJOFL-UHFFFAOYSA-N

Aleph-6, or ALEPH-6, also known as 4-phenylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families.123 It is one of the Aleph series of compounds.123

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-6's dose as greater than 40 mg orally and its duration as "probably long".123 The effects of Aleph-6 have been reported to include "un-worldliness", among others.1 It was reported to have synergized with LSD when taken in combination with it.1 Overall however, Shulgin regarded Aleph-6 as a "disappointment" and that it may be a "forever threshold thing".1

The chemical synthesis of Aleph-6 has been described.12 The 2C analogue, 2C-T-6, has never been synthesized.1

Aleph-6 was first described in the literature by Shulgin in PiHKAL in 1991.123 It is a controlled substance in Canada under phenethylamine blanket-ban language.4

See also

See also

References

References

  1. Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. https://erowid.org/library/books_online/pihkal/pihkal006.shtml
  2. Shulgin A, Manning T, Daley P (2011). The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds. Vol. 1. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
  3. Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  4. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
External links