AKAP7

AKAP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZP3
Identifiers
Aliases	AKAP7, AKAP15, AKAP18, A-kinase anchoring protein 7
External IDs	OMIM: 604693; MGI: 1859150; HomoloGene: 49463; GeneCards: AKAP7; OMA:AKAP7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,283,535 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	25,183,768 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left adrenal gland; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; duodenum; ; mucosa of sigmoid colon; ; pancreatic epithelial cell; ; biceps brachii; ; endothelial cell;
	Top expressed in
	zygote; ; lobe of cerebellum; ; cerebellar vermis; ; secondary oocyte; ; neural layer of retina; ; jejunum; ; duodenum; ; primary motor cortex; ; primary oocyte; ; epithelium of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase A binding; protein binding; nucleotide binding; protein kinase binding; protein kinase A regulatory subunit binding;
Cellular component	plasma membrane; apical plasma membrane; lateral plasma membrane; membrane; intracellular anatomical structure; cytoplasm; cytosol; nucleus; protein-containing complex; hippocampal mossy fiber to CA3 synapse;
Biological process	action potential; protein localization; regulation of membrane repolarization; intracellular signal transduction; ion transport; cellular response to cAMP; positive regulation of delayed rectifier potassium channel activity; positive regulation of potassium ion transmembrane transport; regulation of protein kinase A signaling; biological process; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9465
	432442
	ENSG00000118507
	ENSMUSG00000039166
	O43687; Q9P0M2
	O55074; Q7TN79
NM_004842; NM_016377; NM_138633; NM_001376570; NM_001387860;
	NM_001387861; NM_001387862; NM_001387863; NM_001387864
	NM_018747; NM_001347460; NM_001379238; NM_001379239; NM_001379240
	NP_004833; NP_057461; NP_619539; NP_001363499; NP_057461.2
NP_001334389; NP_061217; NP_001366167; NP_001366168; NP_001366169;
	NP_061217.3
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.⁵⁶

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.⁶

References

GRCh38: Ensembl release 89: ENSG00000118507 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039166 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
"Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

External links

Human AKAP7 genome location and AKAP7 gene details page in the UCSC Genome Browser.

Further reading

Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology. 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC 3188456. PMID 18082768.
Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal. 21 (4): 1189–1201. doi:10.1096/fj.06-6046com. PMID 17244820. S2CID 34457423.
Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications. 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID 12804576.
Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4445–4450. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology. 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC 2174236. PMID 10613906.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039166 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545239-5] Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.

[entrez-6] "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

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