Article · Wikipedia archive · Last revised Aug 6, 2026

Afloqualone

Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.

Last revised
Aug 6, 2026
Read time
≈ 1 min
Length
204 w
Citations
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Source
Wikipedia ↗
Afloqualone
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
  • none
Legal status
Legal status
  • US: Unscheduled
Identifiers
  • 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H14FN3O
Molar mass283.306 g·mol−1
3D model (JSmol)
  • O=C1C2=CC(N)=CC=C2N=C(CF)N1C3=CC=CC=C3C
  • InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 checkY
  • Key:VDOSWXIDETXFET-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.1 It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor2 and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.3

See also

See also

References

References

  1. US 3966731, Inoue I, Oine T, Yamada Y, Tani J, Ishida R, Ochiai T, "2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone", issued 29 June 1976, assigned to Tanabe Seiyaku Co Ltd 
  2. Ochiai T, Ishida R (June 1982). "Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity". Japanese Journal of Pharmacology. 32 (3): 427–38. doi:10.1254/jjp.32.427. PMID 7109348.
  3. Ishikawa T, Kamide R, Niimura M (June 1994). "Photoleukomelanodermatitis (Kobori) induced by afloqualone". The Journal of Dermatology. 21 (6): 430–3. doi:10.1111/j.1346-8138.1994.tb01768.x. PMID 8064007. S2CID 7486566.