Article · Wikipedia archive · Last revised Aug 1, 2026

ADB-HEXINACA

ADB-HEXINACA is a cannabinoid designer drug that has been found as an ingredient in some synthetic cannabis products, first appearing in early 2021. It is a longer chain homologue of previously encountered synthetic cannabinoid compounds such as ADB-BUTINACA and ADB-PINACA. The pharmacology of ADB-HEXINACA and numerous analogues at CB1 and CB2 receptors has been reported.

Last revised
Aug 1, 2026
Read time
≈ 1 min
Length
238 w
Citations
3
Source
Wikipedia ↗
ADB-HEXINACA
Legal status
Legal status
Identifiers
  • N-[(2S)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-hexyl-1H-indazole-3-carboxamide
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H30N4O2
Molar mass358.486 g·mol−1
3D model (JSmol)
  • O=C(N[C@@H](C(C)(C)C)C(N)=O)C1=NN(CCCCCC)C2=C1C=CC=C2
  • InChI=1S/C20H30N4O2/c1-5-6-7-10-13-24-15-12-9-8-11-14(15)16(23-24)19(26)22-17(18(21)25)20(2,3)4/h8-9,11-12,17H,5-7,10,13H2,1-4H3,(H2,21,25)(H,22,26)/t17-/m1/s1
  • Key:PZMLDAGKYPJWHJ-QGZVFWFLSA-N

ADB-HEXINACA (also known as ADB-HINACA and ADMB-HEXINACA) is a cannabinoid designer drug that has been found as an ingredient in some synthetic cannabis products, first appearing in early 2021. It is a longer chain homologue of previously encountered synthetic cannabinoid compounds such as ADB-BUTINACA and ADB-PINACA.12 The pharmacology of ADB-HEXINACA and numerous analogues at CB1 and CB2 receptors has been reported.3

See also

See also

References

References

  1. Kronstrand R, Norman C, Vikingsson S, Biemans A, Valencia Crespo B, Edwards D, et al. (November 2021). "The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons". Drug Testing and Analysis. 14 (4): 634–652. doi:10.1002/dta.3203. PMID 34811926. S2CID 244490343.
  2. Gilbert N, Costello A, Ellison JR, Khan U, Knight M, Linnell MJ, et al. (December 2021). "Synthesis, characterisation, detection and quantification of a novel hexyl-substituted synthetic cannabinoid receptor agonist: (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA)" (PDF). Forensic Chemistry. 26 100354. doi:10.1016/j.forc.2021.100354.
  3. Sparkes E, Timmerman A, Markham JW, Boyd R, Gordon R, Walker KA, et al. (April 2024). "Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA". ACS Chemical Neuroscience. 15 (9): 1787–1812. doi:10.1021/acschemneuro.3c00818. PMID 38597712.