ADAM11

ADAM11
Identifiers
Aliases	ADAM11, MDC, ADAM metallopeptidase domain 11
External IDs	OMIM: 155120; MGI: 1098667; HomoloGene: 7614; GeneCards: ADAM11; OMA:ADAM11 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,781,846 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,671,088 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; apex of heart; ; superior frontal gyrus; ; postcentral gyrus; ; primary visual cortex;
	Top expressed in
	cerebellar cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lobe of cerebellum; ; liver parenchyma; ; cerebellar vermis; ; hippocampus proper; ; habenula; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; metalloendopeptidase activity; metallopeptidase activity;
Cellular component	extracellular matrix; integral component of membrane; plasma membrane; membrane; collagen-containing extracellular matrix;
Biological process	integrin-mediated signaling pathway; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	4185
	11488
	ENSG00000073670
	ENSMUSG00000020926
	O75078
	Q9R1V4
	NM_002390; NM_001318933
	NM_001110778; NM_009613
	NP_001305862; NP_002381
	NP_001104248; NP_033743
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.⁵⁶

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.⁶

References

GRCh38: Ensembl release 89: ENSG00000073670 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020926 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. S2CID 11770397.
"Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".

External links

The MEROPS online database for peptidases and their inhibitors: M12.976 Archived 2005-11-11 at the Wayback Machine
Human ADAM11 genome location and ADAM11 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073670 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020926 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8252040-5] Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. S2CID 11770397.

[entrez-6] "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".

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References

Further reading

External links