ACP2

ACP2
Identifiers
Aliases	ACP2, acid phosphatase 2, lysosomal, LAP
External IDs	OMIM: 171650; MGI: 87882; HomoloGene: 1217; GeneCards: ACP2; OMA:ACP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,248,906 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,044,443 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; stromal cell of endometrium; ; jejunal mucosa; ; left adrenal cortex; ; mucosa of transverse colon; ; salivary gland;
	Top expressed in
	spermatocyte; ; medial dorsal nucleus; ; stroma of bone marrow; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; choroid plexus of fourth ventricle; ; medial geniculate nucleus; ; ascending aorta; ; aortic valve; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; acid phosphatase activity;
Cellular component	integral component of membrane; lysosomal membrane; lysosome; lysosomal lumen; extracellular exosome; membrane;
Biological process	skeletal system development; lysosome organization; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	53
	11432
	ENSG00000134575
	ENSMUSG00000002103
	P11117
	P24638
NM_001131064; NM_001302489; NM_001302490; NM_001302491; NM_001302492;
	NM_001610; NM_001357016
	NM_007387; NM_001357067
NP_001289418; NP_001289419; NP_001289420; NP_001289421; NP_001601;
	NP_001343945
	NP_031413; NP_001343996
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.⁵⁶

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.⁶

References

GRCh38: Ensembl release 89: ENSG00000134575 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002103 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.
"Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

External links

Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134575 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002103 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid975882-5] Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.

[entrez-6] "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

1

2

3

4

5

6

References

Further reading

External links