Article · Wikipedia archive · Last revised Jul 19, 2026

Acetyldigitoxin

Acetyldigitoxin is a cardiac glycoside. It is an acetyl derivative of digitoxin, found in the leaves of Digitalis species. It is used to treat cardiac failure, particularly that associated with tachycardia.

Last revised
Jul 19, 2026
Read time
≈ 1 min
Length
140 w
Citations
3
Source
Wikipedia ↗
Acetyldigitoxin
Clinical data
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)1
Identifiers
  • [(2R,3R,4S,6S)-3-Hydroxy-6-[(2R,4S,6S)-4-hydroxy-6-[(2R,3S,4S,6R)-4-hydroxy-6-[ [(5R,8R,9S,10S,13R,14S,17R')-14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-2-methyloxan-3-yl]oxy-2-methyloxan-3-yl]oxy-2-methyloxan-4-yl] acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.042.660
Chemical and physical data
FormulaC43H66O14
Molar mass806.987 g·mol−1
3D model (JSmol)
  • O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)CC[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@@H]([C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@H](OC(=O)C)C3)[C@@H](O)C4)C)[C@@H](O)C5)C)C6
  • InChI=1S/C43H66O14/c1-21-38(48)33(54-24(4)44)19-37(51-21)57-40-23(3)53-36(18-32(40)46)56-39-22(2)52-35(17-31(39)45)55-27-9-12-41(5)26(16-27)7-8-30-29(41)10-13-42(6)28(11-14-43(30,42)49)25-15-34(47)50-20-25/h15,21-23,26-33,35-40,45-46,48-49H,7-14,16-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29+,30-,31+,32+,33+,35+,36+,37+,38-,39-,40-,41+,42-,43+/m1/s1
  • Key:HPMZBILYSWLILX-UMDUKNJSSA-N

Acetyldigitoxin is a cardiac glycoside. It is an acetyl derivative of digitoxin, found in the leaves of Digitalis species.2 It is used to treat cardiac failure, particularly that associated with tachycardia.3

References

References

  1. "Therapeutic Goods (Poisons Standard— June 2025) Instrument 2025" (pdf). Therapeutic Goods Administration (TGA). May 2025. Retrieved 31 August 2025.
  2. Kemertelidze ÉP, Gvazava LN (1 November 1979). "Odorobioside G from the leaves ofDigitalis ciliata". Chemistry of Natural Compounds. 15 (6): 779. doi:10.1007/BF00565608.
  3. Loffler W, Essellier AF, Forster G (June 1954). "Acetyl-digitoxin; clinical observations on the treatment of patients with advanced congestive heart failure". American Heart Journal. 47 (5): 898–911. doi:10.1016/0002-8703(54)90160-X. PMID 13158272.