Article · Wikipedia archive · Last revised Jun 5, 2026

4-HO-NET

4-HO-NET, also known as 4-hydroxy-N-ethyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT). It was not included by Alexander Shulgin in his 1997 book TiHKAL and its properties and effects in humans are unknown. The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor. It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lower potency than psilocin (4-HO-DMT). Unlike 4-HO-NET, norpsilocin is notably inactive in this test. In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents. 4-HO-NET was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.

Last revised
Jun 5, 2026
Read time
≈ 1 min
Length
216 w
Citations
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Source
Wikipedia ↗
4-HO-NET
Clinical data
Other names4-Hydroxy-N-ethyltryptamine
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • 3-[2-(ethylamino)ethyl]-1H-indol-4-ol
PubChem CID
ChemSpider
Chemical and physical data
FormulaC12H16N2O
Molar mass204.273 g·mol−1
3D model (JSmol)
  • CCNCCC1=CNC2=C1C(=CC=C2)O
  • InChI=1S/C12H16N2O/c1-2-13-7-6-9-8-14-10-4-3-5-11(15)12(9)10/h3-5,8,13-15H,2,6-7H2,1H3
  • Key:AGYHPYWJOGSFII-UHFFFAOYSA-N

4-HO-NET, also known as 4-hydroxy-N-ethyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT).1 It was not included by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.2 The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor.1 It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lower potency than psilocin (4-HO-DMT).1 Unlike 4-HO-NET, norpsilocin is notably inactive in this test.1 In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents.1 4-HO-NET was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.1

See also

See also

References

References

  1. Sherwood AM, Burkhartzmeyer EK, Williamson SE, Baumann MH, Glatfelter GC (January 2024). "Psychedelic-like Activity of Norpsilocin Analogues". ACS Chemical Neuroscience. 15 (2): 315–327. doi:10.1021/acschemneuro.3c00610. PMC 10797613. PMID 38189238.
  2. Shulgin A, Shulgin A (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
External links