3F-NEB

3F-NEB
Legal status
Legal status	DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B;
Identifiers
	IUPAC name 2-(ethylamino)-1-(3-fluorophenyl)butan-1-one;
PubChem CID	164946359;
CompTox Dashboard (EPA)	DTXSID901343028 ;
Chemical and physical data
Formula	C12H16FNO
Molar mass	209.264 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C(=O)C1=CC(=CC=C1)F)NCC;
	InChI InChI=1S/C12H16FNO/c1-3-11(14-4-2)12(15)9-6-5-7-10(13)8-9/h5-8,11,14H,3-4H2,1-2H3; Key:FLFAFGGBRUXYBD-UHFFFAOYSA-N;

3-Fluoro-N-ethylbuphedrone (3F-NEB) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug.¹ It was first identified in Sweden in 2021.²³

References

Pain S, Nadal-Gratacós N, De Macedo M, Lardeux V, Mata S, Puigseslloses P, et al. (February 2026). "Neurochemical and behavioral evidence of high abuse liability of 3F-NEB, a novel synthetic cathinone". European Journal of Pharmacology. 1015 178570. doi:10.1016/j.ejphar.2026.178570. hdl:20.500.14342/5980. PMID 41554370.
European Monitoring Centre for Drugs and Drug Addiction. (June 2022). New psychoactive substances: 25 years of early warning and response in Europe. An update from the EU Early Warning System. European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/396103. ISBN 978-92-9497-737-3.
Kuropka P, Zawadzki M, Szpot P (September 2022). "A review of synthetic cathinones emerging in recent years (2019-2022)". Forensic Toxicology. 41 (1): 25–46. doi:10.1007/s11419-022-00639-5. PMC 9476408. PMID 36124107.

[1] Pain S, Nadal-Gratacós N, De Macedo M, Lardeux V, Mata S, Puigseslloses P, et al. (February 2026). "Neurochemical and behavioral evidence of high abuse liability of 3F-NEB, a novel synthetic cathinone". European Journal of Pharmacology. 1015 178570. doi:10.1016/j.ejphar.2026.178570. hdl:20.500.14342/5980. PMID 41554370.

[2] European Monitoring Centre for Drugs and Drug Addiction. (June 2022). New psychoactive substances: 25 years of early warning and response in Europe. An update from the EU Early Warning System. European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/396103. ISBN 978-92-9497-737-3.

[pmid36124107-3] Kuropka P, Zawadzki M, Szpot P (September 2022). "A review of synthetic cathinones emerging in recent years (2019-2022)". Forensic Toxicology. 41 (1): 25–46. doi:10.1007/s11419-022-00639-5. PMC 9476408. PMID 36124107.

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See also

References