Article · Wikipedia archive · Last revised Aug 8, 2026

2CE-5iPrO

2CE-5iPrO, also known as 5-iPrO-2C-E or as 2-methoxy-5-isopropoxy-4-ethylphenethylamine, is a psychedelic substituted phenethylamine derivative related to 2C-E, but with the 5-methoxy group extended to isopropoxy. Similar to related "tweetio" compounds such as 2CD-5EtO, it has a longer duration of action than 2C-E but is otherwise similar in activity, although it shows reduced anti-inflammatory actions. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

Last revised
Aug 8, 2026
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≈ 1 min
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2CE-5iPrO
Clinical data
Other names2CE-5-iPrO; 5-iPrO-2C-E; 2-Methoxy-5-isopropoxy-4-ethylphenethylamine; 2-Methoxy-4-ethyl-5-isopropoxyphenethylamine
Drug classSerotonin receptor modulator
Identifiers
  • 1-(5-(propan-2-yloxy)-2-methoxy-4-ethylphenyl)-ethan-1-amine
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC14H23NO2
Molar mass237.343 g·mol−1
3D model (JSmol)
  • COc1cc(CC)c(cc1CCN)OC(C)C
  • InChI=1S/C14H23NO2/c1-5-11-8-13(16-4)12(6-7-15)9-14(11)17-10(2)3/h8-10H,5-7,15H2,1-4H3
  • Key:WBECSSJDHFYNMA-UHFFFAOYSA-N

2CE-5iPrO, also known as 5-iPrO-2C-E or as 2-methoxy-5-isopropoxy-4-ethylphenethylamine, is a psychedelic substituted phenethylamine derivative related to 2C-E, but with the 5-methoxy group extended to isopropoxy. Similar to related "tweetio" compounds such as 2CD-5EtO, it has a longer duration of action than 2C-E but is otherwise similar in activity, although it shows reduced anti-inflammatory actions.1 The drug is a controlled substance in Canada under phenethylamine blanket-ban language.2

See also

See also

References

References

  1. Flanagan TW, Billac GB, Landry AN, Sebastian MN, Cormier SA, Nichols CD (April 2021). "Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore". ACS Pharmacology & Translational Science. 4 (2): 488–502. doi:10.1021/acsptsci.0c00063. PMC 8033619. PMID 33860179.
  2. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
External links