Article · Wikipedia archive · Last revised Jul 21, 2026

2CD-5EtO

2CD-5EtO, also known as 5-ethoxy-2-methoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to 2C-D. It is the analogue of 2C-D in which the methoxy group at the 5 position has been extended to an ethoxy group.

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Jul 21, 2026
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2CD-5EtO
Clinical data
Other names2C-D-5-EtO; 2CD-5-EtO; 5-Ethoxy-2-methoxy-4-methylphenethylamine; 2-Methoxy-5-ethoxy-4-methylphenethylamine; 4-Methyl-2-methoxy-5-ethoxyphenethylamine; 2-Methoxy-4-methyl-5-ethoxyphenethylamine
Routes of
administration		Oral1
Drug classPsychoactive drug
Pharmacokinetic data
Onset of action~2 hours (peak)1
Duration of action12 hours123
Identifiers
  • 1-(5-ethoxy-2-methoxy-4-methylphenyl)-ethan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H19NO2
Molar mass209.289 g·mol−1
3D model (JSmol)
  • CCOC1=CC(=C(C=C1C)OC)CCN
  • InChI=1S/C12H19NO2/c1-4-15-11-8-10(5-6-13)12(14-3)7-9(11)2/h7-8H,4-6,13H2,1-3H3 checkY
  • Key:ZMQDQUPRBYFPSO-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2CD-5EtO, also known as 5-ethoxy-2-methoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to 2C-D.123 It is the analogue of 2C-D in which the methoxy group at the 5 position has been extended to an ethoxy group.123

In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 2CD-5EtO's dose as 40 to 50 mg orally, its onset as slow and gradual, its time to peak or full effects as about 2 hours, and its duration as 12 hours.123 The effects of 2CD-5EtO were said to include being "largely free from excitement", having "a friendly openness and outgoingness that allowed easy talk, interaction, humor", and allowing for healthy appetite.1

The chemical synthesis of 2CD-5EtO has been described.1

2CD-5EtO was first described in the literature by Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991.1 It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.24567 2CD-5EtO is a controlled substance in Canada under phenethylamine blanket-ban language.8

See also

See also

References

References

  1. Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. https://www.erowid.org/library/books_online/pihkal/pihkal023.shtml#:~:text=2CD%2D5ETO
  2. Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  3. Jacob P, Shulgin AT (1994). "Structure-activity relationships of the classic hallucinogens and their analogs". NIDA Research Monograph. 146: 74–91. PMID 8742795.
  4. "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
  5. Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
  6. Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
  7. Lazar (Darrell Lemaire), Hosteen Nez (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
  8. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
External links