Article · Wikipedia archive · Last revised Jul 19, 2026

2C-E-FLY

2C-E-FLY is a recreational designer drug with psychedelic effects of the phenethylamine, 2C, and FLY families. It is slightly less potent than 2C-E or 2C-B-FLY in animal studies but retains drug-appropriate responding. It is a controlled substance in Canada under phenethylamine blanket-ban language.

Last revised
Jul 19, 2026
Read time
≈ 1 min
Length
226 w
Citations
4
Source
Wikipedia ↗
2C-E-FLY
Clinical data
Drug classSerotonergic psychedelic; Hallucinogen
Legal status
Legal status
  • In general unscheduled
Identifiers
  • 2-(8-Ethyl-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b′]difuran-4-yl)ethan-1-amine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H19NO2
Molar mass233.311 g·mol−1
3D model (JSmol)
  • NCCc1c2OCCc2c(c2c1CCO2)CC
  • InChI=1S/C14H19NO2/c1-2-9-11-4-7-17-14(11)10(3-6-15)12-5-8-16-13(9)12/h2-8,15H2,1H3
  • Key:JLKXEQOGLSSESL-UHFFFAOYSA-N

2C-E-FLY is a recreational designer drug with psychedelic effects of the phenethylamine, 2C, and FLY families. It is slightly less potent than 2C-E or 2C-B-FLY in animal studies but retains drug-appropriate responding.123 It is a controlled substance in Canada under phenethylamine blanket-ban language.4

See also

See also

References

References

  1. Wagmann L, Brandt SD, Stratford A, Maurer HH, Meyer MR (February 2019). "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases". Drug Testing and Analysis. 11 (2): 318–324. doi:10.1002/dta.2494. PMID 30188017. S2CID 52166076.
  2. Halberstadt AL, Chatha M, Stratford A, Grill M, Brandt SD (January 2019). "Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs". Neuropharmacology. 144: 368–376. doi:10.1016/j.neuropharm.2018.10.037. PMC 6863604. PMID 30385253.
  3. Wagmann L, Hempel N, Richter LH, Brandt SD, Stratford A, Meyer MR (October 2019). "Phenethylamine-derived new psychoactive substances 2C-E-FLY, 2C-EF-FLY, and 2C-T-7-FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings". Drug Testing and Analysis. 11 (10): 1507–1521. doi:10.1002/dta.2675. PMID 31299701. S2CID 196350806.
  4. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.