Article · Wikipedia archive · Last revised Jul 2, 2026

2-APQC

2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice.

Last revised
Jul 2, 2026
Read time
≈ 1 min
Length
134 w
Citations
2
Source
Wikipedia ↗
2-APQC
Clinical data
Drug classSirtuin-3 (SIRT3) activator
Identifiers
  • 2-amino-1-[(4-fluorophenyl)methyl]-N-pentylpyrrolo[3,2-b]quinoxaline-3-carboxamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC23H24FN5O
Molar mass405.477 g·mol−1
3D model (JSmol)
  • CCCCCNC(=O)C1=C(N(C2=NC3=CC=CC=C3N=C12)CC4=CC=C(C=C4)F)N
  • InChI=1S/C23H24FN5O/c1-2-3-6-13-26-23(30)19-20-22(28-18-8-5-4-7-17(18)27-20)29(21(19)25)14-15-9-11-16(24)12-10-15/h4-5,7-12H,2-3,6,13-14,25H2,1H3,(H,26,30)
  • Key:FYNPHMNXVLLDAS-UHFFFAOYSA-N

2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice.12

References

References

  1. Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, et al. (May 2024). "2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis". Signal Transduction and Targeted Therapy. 9 (1) 133. doi:10.1038/s41392-024-01816-1. PMC 11094072. PMID 38744811.
  2. Xu C, Xiong L, Chen J, Liu Q, Wang F, Fu X, et al. (2025). "Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia". American Journal of Translational Research. 17 (6): 4187–4197. doi:10.62347/JWEY8421. PMC 12261155. PMID 40672597.