Article · Wikipedia archive · Last revised Jul 11, 2026

1SB-LSD

1SB-LSD, or 1BS-LSD, also known as 1-TMSBz-LSD or as 1-(4- benzoyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is thought to be a prodrug of LSD. The drug was encountered online as a novel designer drug in September 2025. 1SB-LSD has been sold in the form of blotter, for instance containing 165 μg per tab. It is the derivative of 1Bz-LSD (SYN-L-018) in which there is a 4-trimethylsilyl group on the benzyl ring. 1SB-LSD was first described in the scientific literature by 2026. It is not an explicitly controlled substance in the United States or in Canada.

Last revised
Jul 11, 2026
Read time
≈ 1 min
Length
244 w
Citations
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Source
Wikipedia ↗
1SB-LSD
Clinical data
Other names1BS-LSD; 1-TMSBz-LSD; 1-(4-(Trimethylsilyl)benzoyl)-LSD
Routes of
administration		Oral1
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Chemical and physical data
FormulaC30H36N3O2Si
Molar mass498.722 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C]1CN(C)[C@@H]2Cc3cn(C(=O)c4ccc(cc4)[Si](C)(C)C)c5cccc(C2=C1)c35
  • InChI=1S/C30H36N3O2Si/c1-7-32(8-2)29(34)22-16-25-24-10-9-11-26-28(24)21(17-27(25)31(3)18-22)19-33(26)30(35)20-12-14-23(15-13-20)36(4,5)6/h9-16,19,27H,7-8,17-18H2,1-6H3/t27-/m1/s1
  • Key:SLFZGAWRMZEIEW-HHHXNRCGSA-N

1SB-LSD, or 1BS-LSD, also known as 1-TMSBz-LSD or as 1-(4-(trimethylsilyl)benzoyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).12 It is thought to be a prodrug of LSD.1 The drug was encountered online as a novel designer drug in September 2025.12 1SB-LSD has been sold in the form of blotter, for instance containing 165 μg per tab.12 It is the derivative of 1Bz-LSD (SYN-L-018) in which there is a 4-trimethylsilyl group on the benzyl ring.123 1SB-LSD was first described in the scientific literature by 2026.2 It is not an explicitly controlled substance in the United States4 or in Canada.5

See also

See also

References

References

  1. "1BS-LSD". AIPSIN (in Russian). Retrieved 1 January 2026.
  2. Tanaka R, Kawamura M, Ito M, Kikura-Hanajiri R (April 2026). "Identification and Analysis of Lysergic Acid Diethylamide Analogs, 4-Benzoyl-N,N-Diethyl-7-Methyl-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1Bz-LSD) and N,N-Diethyl-7-Methyl-4-(4-(Trimethylsilyl)Benzoyl)-4,6,6a,7,8,9-Hexahydroindolo[4,3-fg]quinoline-9-Carboxamide (1-TMSBz-LSD), in tablet or paper sheet products available online in Japan". Drug Test Anal. 18 (4): 510–517. doi:10.1002/dta.70039. PMID 41709646.
  3. WO 2024/028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
  4. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  5. "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.